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In addition, it has been shown that melatonin is responsible for the restoration of Mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) mRNA levels, and the consequent sustaining of mitochondrial fusion in a PGC1α-dependent manner [187]
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Although several published RCTs have shown inconsistent findings, most studies have suggested that dietary, exercise, and drug interventions can enhance SIRT signaling, and SIRT activators played an important role in physiological functions by activating SIRTs
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