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Glutathione and Iron Interplay in Alzheimer's: A Clue for Intervention? | Research Communities by Springer Nature
Although this mechanism remains hypothetical, studies on xCT-knockout mice, which are unable to export cellular Glu in exchange for extracellular cystine, suggest a reduction in excitotoxicity [45,164] and indirectly support this hypothetical mechanism
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Oxidized phospholipids and ferroptosis as mechanisms of antitumor immunity OxPLs such as OxPAPC and PGPC can induce long-term activation of dendritic cells, the so-called “hyperactivation state.” 81 Extracellular protein CD14 binds OxPLs and translocates them into dendritic cells thus leading to inflammasome activation and production of large amounts of interleukin-1β, known as an active regulator of differentiation of T cells and their effector functions
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