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Common Chronic Fatigue Symptoms Symptoms of CFS can vary from one person to another, although some of the more common ones include: Extreme tiredness, you may feel permanently exhausted, even after a good night sleep Trouble sleeping or staying asleep Difficulty to think or focus, “brain fog” Constant headache Can’t tolerate standing for a long time Enlarged lymph nodes in your armpits or neck Sore throat Joint or muscle pain GI issues such as bloating, excess gas, burping after meal, diarrhea or constipation Know the early warning signs & timeline Symptoms of chronic fatigue do not occur overnight, and usually evolve over time