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These relationships are complex, and research into the gut-immune connection does not establish that “leaky gut” directly causes autoimmune disease
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However, IL-10’s role in cancer-related T cell exhaustion appears to differ, and reduced IL-10 levels may impair cancer immunotherapy outcomes.[ref][ref] ADRB1 (β1-adrenergic receptor): β1-adrenergic signaling through ADRB1 has recently been identified as having a role in T cell exhaustion
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