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Intracellular GSH depletion and APP Swedish/Indiana mutation synergistically induce ferroptosis in SH-SY5Y cells To determine the mechanism underlying cell death, APP Swe/Ind -overexpressing cells were co-treated with BSO and either pan-caspase inhibitor Z-VAD-FMK or the ferroptosis inhibitors ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1), to assess whether cell death occurred through apoptosis or ferroptosis
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