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The Holistic Treatment of Chronic Lyme Disease Part 3 - Longevity Health

10.1080/21691401.2020.1770271 [DOI] [PubMed] [Google Scholar] Khezri K., Saeedi M., Morteza-Semnani K., Akbari J., Rostamkalaei S

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Phase II Metabolism Images Overview oxidation (via cytochrome P450), reduction, and hydrolysis reactions phase I reactions convert a parent drug to more polar (water soluble) active metabolites by unmasking or inserting a polar functional group (-OH, -SH, -NH2) geriatric patients have decreased phase I metabolism drugs metabolized via phase I reactions have longer half-lives geriatric patients metabolism drugs by phase II reactions Phase II metabolism glucuronidation, acetylation, and sulfation reactions "conjugation reactions" that increase water solubility of drug with a polar moiety phase II reactions convert a parent drug to more polar (water soluble) inactive metabolites by conjugation of subgroups to -OH, -SH, -NH2 functional groups on drug patients deficient in acetylation capacity (slow acetylators) may have prolonged or toxic responses to normal doses of certain drugs because of decreased rates of metabolism oral intake of medications result in processing by the liver prior to reaching the systemic circulation systemic concentrations can be far lower than that initially absorbed Create a free account or log in to see the cards.