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In addition, peroxisomal oxidases and xanthine oxidases generate ROS and nitric oxide ( • via proton translocation to maintain an optimal pH for acidic hydrolases ( Thus, ROS are produced as a byproduct of cellular events wherein the NOX family of proteins mediate the reduction of O 2 to O 2 •- and phagocytes NOX accounts for an increased amount of O 2 •- and H 2 O 2 production by respiratory burst ( 2 •- production
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