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The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer's disease | Molecular Neurodegeneration | Springer Nature Link
Hyperglycemia can produce excess free radicals and oxidative stress, damage hippocampal neurons, and is associated with cognitive impairment (58)
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Several nanoparticles with enhanced delivery abilities have been developed as well, which includes those attached to the silica core protected by poly(ethylene glycol) chains (PluS–NO), CdSe quantum dots, rotaxane-branched radical dendrimers (Gn-TEMPO), G4-polyamidoamine dendrimers, 3Gc0T zero-generation dendrimer, polyurethane dendrimers, gold nanoparticles, liquid crystal nanoparticles, nanosized sterically stabilized liposomes, poly[oligo(ethylene glycol)methyl ether acrylate] and poly(2-hydroxyethyl acrylate) conjugates, and redox nanoparticles
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