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Kwon and co-authors used homoplasmic lettuce cell lines to express codon optimized FVIII protein, which resulted in high level expression of CTB fused FVIII HC, light chain (LC: A3, C1 and C2 domains), C2 domain and the entire BDD human FVIII protein (SC) in chloroplasts to levels required for clinical translation [52]

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This suggests that Neto proteins alter the conformation of the ion channel pore or the access pathway for polyamines, a common feature of kainate receptor auxiliary subunit modulation 37