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Conversely, other studies have demonstrated that lactic acid may partially restore PGC-1α activity, reduce the expression of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, alleviate renal injury, and improve survival in murine models of sepsis-induced AKI ( In addition, lipid-derived mediators produced from the autoxidation of intracellular polyunsaturated FAs, such as α-linolenic acid and docosahexaenoic acid (DHA), exhibit anti-inflammatory effects (Zhang et al., 2025
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