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Furthermore, another group demonstrated that 1) mutation of the four serine/threonine residues between residues 355 and 364 in β 2 -AR C-terminus resulted in a loss of agonist-induced β 2 -AR- β -Arr 2 interactions and receptor internalization and 2) β 2 -AR truncation distal to residue 381 compromised receptor internalization but did not affect β -Arr 2 (Krasel et al., 2008)