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A diferencia de las estructuras proteicas complejas o de los análogos sintéticos que requieren modificaciones covalentes masivas para su estabilidad, la arquitectura molecular del DSIP original carece de puentes disulfuro intramoleculares o bioconjugaciones exógenas, exhibiendo un residuo de triptófano en su extremo amino-terminal y ácido glutámico en su extremo carboxilo-terminal
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