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High glucose exposure of the endothelial and pericytes cells in retina exhibits the aggravation of oxidative stress, leading to the increase of Caspase-3 activity, NF-κB or other transcription factors to accelerate capillary cell death
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Meanwhile, liquid biopsy technologies based on blood or plasma, especially by means of analyzing circulating free DNA (cfDNA) and circulating tumor DNA (ctDNA), have shown significant value in the diagnosis of BC, disease-free survival (DFS) (Silva et al., 2002) prediction, and the assessment and personalized management of triple-negative breast cancer (TNBC) (Ortolan et al., 2021
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