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In contrast, IFN-γ -deficient mice were less susceptible to alopecia areata (Figure 1) that destroys anagen hair follicles and leads to alopecia areata ( Figure 1 Besides CD8+ NKG2D+ T cells and IFN-γ, some inflammatory cells and cytokines also play a significant role in the immune pathogenesis of alopecia areata, such as dendritic cells, CD4 + T cells, NK T cells, mast cells and eosinophils, and other cytokines such as IL-2, CXCLs, and TNF-α

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