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Therefore, proinflammatory cytokines and intracellular proteins are the targets of many treatments for moderate to severe UC, including monoclonal antibodies to TNF-α and IL-12/23 receptors, which affect these pathways
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680,681,682 Small molecules targeting ferroptosis by regulating the ACSL4-LOX axis Lipid peroxidation is a hallmark of ferroptosis, and lipid-metabolizing enzymes such as ACSL4 and LOX contribute to ferroptosis
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