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By inhibiting mitochondrial respiratory chain complex I, metformin increases the cellular AMP: ATP ratio, which in turn activates AMPK (86, 88)

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During the first day of acquisition training, female 12-month-old Tg4-42 and WT animals used predominantly a ‘random search’ strategy (Table S1, WT: 63%, Tg4-42: 92%) to locate the hidden platform