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Experimental autoimmune encephalomyelitis (EAE) is a CD4 + T-cell mediated autoimmune disease model and is robustly used to study innate and adaptive immune components and their interactions with the central nervous system (CNS) (Ryu et al., 2018)
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In summary, the brain microvascular endothelium differs from peripheral endothelium in three primary ways: 42 Transport Across the Blood-Brain Barrier The biochemical BBB is established by transport systems of the BBB, which can be grouped into four types (Fig
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