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Furthermore, a second mechanism involved would be related to TGF-β-dependent apoptotic processes, producing an increase in caspase 8, which in turn acts as an inducer of caspases 3, 6 and 7, giving rise to apoptosis [29,46]
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These mediators, including microbial structural components and metabolic byproducts, act as “molecular messengers” that transduce local microbial activity into systemic physiological or pathological responses (Fig
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