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PS linkages and OMe positioned at the terminals are used to enhance the capability of siRNA to resist degrading enzyme attack

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“The current indications for biologics in ulcerative colitis are for people who haven’t responded to traditional medications or are dependent on corticosteroids to relieve their symptoms,” says Thomas Ullman, MD, a professor of medicine in the division of gastroenterology at Mount Sinai in New York City and the director of the Westchester branch of Mount Sinai’s Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center