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In fact, we think that the phenotypic rescue might occur through a metabolic route rather than a vascular route, because vB12 treatment began in juvenile mice, when the brain vascular network is fully formed
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Chen et al., 2003) and overexpression of Nrf1 and Nrf2 has been shown to induce the human GCLC promoter activity (Myhrstad et al., 2001
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