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As with BioID, APEX uses harsh cell lysis conditions, and proteins are recovered via streptavidin affinity purification and identified by MS
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In addition to regulating ATII synthesis, angiotensin–converting enzyme (ACE) is primarily responsible for the degradation of a tetrapeptide, acetyl-N-Ser-Asp-Lys-Pro (AcSDKP), an endogenous physiologic inhibitor of hematopoiesis
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