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In particular, activated PLC hydrolyzes the membrane lipid phosphatidylinositol-4,5 bisphosphate (PIP2), to produce second messengers, i.e., inositol triphosphate (IP3) and diacylglycerol (DG)
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Without blinding and randomisation, selection effects, placebo effects and biases cannot be excluded, which is why such mortality figures do not qualify as proof of efficacy
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