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As non-heme iron-containing dioxygenases, lipoxygenases (LOXs) directly catalyze the peroxidation of PUFAs, both free and esterified in phospholipids (77, 78)
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have utilised the melanoma cells expressing analogue-sensitive CDK5, which made it possible to specifically inhibit CDK5 in cancer cells, clearly demonstrating that inhibition of CDK5 in melanoma cells inhibits the metastatic spread of melanoma [194]
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