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18%), and diffuse pediatric-type LGGs ( V600E occurs at lower frequency in pHGG (6-14%) a histopathologically and clinical diverse group of tumors ( V600E expression when coinciding with CDKN2A deletion marks a clinicopathologic subgroup of pLGG at high-risk for progression ( V600E is the most frequent recurrent mutation in secondary pHGGs, occurring in 39% of cases ( BRAF V600E -mutated pLGG occurred most frequently in hemispheric regions (56%) but were also common in the diencephalon (29%)
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