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Compound 40 evicts TRF1 from the shelterin complex We developed a mass-photometry based assay to evaluate the ability of compound 40 to disrupt the TRF1 TRFH :TIN2 TBM interaction and subsequently evict TRF1 from the full shelterin complex
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Analysis of the Injured Area with Special Histochemical Sirius Red Staining Collagen proliferation on Sirius red staining was significantly increased in the treated animals compared to the controls at all three time intervals, 1, 2, and 3 weeks after injury (Figure 19 and Figure 20)
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