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Mutations in isocitrate dehydrogenase, succinate dehydrogenase and fumarate hydratase lead to the accumulation of the neomorphic oncometabolite 2-hydroxyglutarate (2-HG), succinate or fumarate respectively, contributing to the development and the progression of several cancers (150)
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[PubMed] [Google Scholar] 100.Wong V, Cheuk DK, Lee S, Chu V
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