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3.3 The Down-Stream Regulatory Mechanisms of Ferroptosis 3.3.1 Ferroptosis and Mitochondrion Mitochondria are the most abundant organelles in cardiomyocytes, which are mainly responsible for energy metabolism (Li N
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Furthermore, Fe 2+ can catalyze the generation of more toxic hydroxyl radicals (·OH) from H 2 O 2 through the Fenton reaction (Oracz and Zyzelewicz, 2019), thereby exacerbating oxidative stress levels
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