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Inhibitor concentration and pre- and co-treatment protocols must be empirically determined based on cell density, duration of exposure, and unique drug-drug interactions
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Other modifications include halogenation such as chlorination (Andreu and Rivas, 2003), phosphorylation, which can increase stability (McDonald et al., 2011) or hydroxylation, mainly observed at lysine, arginine, tryptophan, and phenylalanine residues with differing effects on antifungal activity (Houwaart et al., 2014
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