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Fatigue alone is not a diagnosis: anemia, thyroid disease, infection, sleep disorders, depression, medication effects, nutritional deficiency, and systemic illness require assessment before vitamins are prescribed

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Methylfolate Although both folinic acid and methylfolate are forms of active folate, they serve distinct biological purposes: Folinic acid (leucovorin) primarily supports the synthesis of DNA, RNA, histones, GTP, nitric oxide (NO), and tetrahydrobiopterin (BH4)—key molecules in cellular growth and neurotransmitter production

Deficiencies may result in anemia