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31 In general, chronic exposure to High-Intensity Sweetenerseven at doses within or below the established acceptable daily intake disrupts female reproductive physiology through compound-specific mechanisms, including HPG axis suppression, ovarian mitochondrial dysfunction, and gut microbiota-induced estrogen depletion, leading to altered timing of puberty and menstrual irregularities
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doi: 10.1128/JVI.01663-10
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