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Additionally, they suppress the NLRP3 inflammasome, downregulating IL-1β and mitigating inflammatory responses (Qiu et al., 2023)
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Thanks to the activation of the TLR4 pathway, Ikb-α is phosphorylated and degraded by proteasome, leading to NFkB release and translocation into the nucleus to increase the expression of targeting genes implicated in the inflammatory response [36,37]
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