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it blocked the binding area of TIGIT to the poliovirus receptor (or CD155), enhanced the function of CD8 + T cells, and inhibited tumor growth 106
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Analgesic and others modulatory roles of melatonin The molecular pathways underlying the analgesic action of melatonin have not been completely addressed, and a plethora of mechanisms have been proposed, such as endorphin release from the pituitary gland 83 , modulation of the central GABAergic system 84 , and additional interaction with multiple receptor types
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