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In this assay, lipid peroxidation is determined by the reaction of MDA with thiobarbituric acid (TBA) to form a colorimetric product (532 nm), which is directly proportional to the MDA concentration
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This article reviews the pathophysiology of acetaminophen metabolism, the clinical and diagnostic clues of an acute overdose, differential diagnoses, and management approaches including the use of the antidote, N -acetylcysteine (NAC), for acute acetaminophen overdose and toxicity in pediatric patients
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